Title of the Thesis “Integrated Proteomic and Metabolomic Analysis Identifies Altered Taurine Metabolism in Breast Cancer” 

Abstract:

Metabolic reprogramming is a hallmark of cancer, enabling tumour cells to meet the demands of rapid proliferation and adapt to their microenvironment. Integrated proteomics and metabolomics analysis are useful for understanding cancer metabolism as they can determine the direct state of the cell by revealing protein abundance and metabolite levels which are the ultimate downstream products of the gene-protein-metabolite axis. With these two techniques, the altered metabolism of breast tumour cells can be differentiated from the metabolism of surrounding normal cells by analyzing both the breast tumour and adjacent normal tissue containing adipocytes, immune cells, epithelial cells, endothelial cells and other stromal cells. In this study an integrated proteomic and metabolomic approach was used to compare tumour and surrounding normal tissue samples from breast cancer patients. 

September 5, 2025, 1:00pm in AVC 287N 

Everyone is welcome to attend.